Endocrine Abstracts

Introduction: Natural history of adrenal incidentalomas has not been totally understood. Current data from subjects with adrenal incidentalomas demonstrated an increased rate of metabolic disturbances and cardiovascular risk. It has been shown that subjects with subclinical cortisol excess were more susceptible to diabetes, hypertension, and obesity. However, there is no data regarding prospective cardiovascular risk evaluation in subjects with subclinical Cushing’s syndr...

The association of thymoma with myasthenia gravis is well known, however association of these two syndromes (Thymoma+Myasthenia gravis) with Addison’s disease is very rare. In here we report myasthenia gravis and autoimmune Addison’s disease in a patient with thymoma.A 32-year-old man was admitted to our hospital with symptoms of weakness, anorexia, nausea, vomiting, pigmentation of skin and mucous membranes for 2 years. He had undergone to the...

BackgroundThe protean and non-specific nature of diagnostic criteria of Hashimoto’s thyroiditis leads either to overdiagnosis or underdiagnosis. The aim of this study is to propose a comprehensive diagnostic scoring system based on objective clinic-investigative criteria.MethodsA case-control study of patients who underwent surgical thyroidectomy, were compared a with a set of clinical, biochemical, path...

IntroductionGrave’s disease is an autoimmune disease characterized by hyperthyroidism. It is in some cases associated to more autoimmune organs dysfunction. The antithyroid drugs are the first line treatement, and sometimes they are responsible for severe adverse effects.ObservationWe report the case of a 34 year-old man, treated for his grave’s disease with thiamazol for two years. Two weeks after ...

IntroductionThe Carney Complex (CNC) is a rare, autosomal dominant, multiple endocrine neoplasia. It involves multiple endocrine glands, cardiac and skin myxomas, mammary fibroadenomas and mucocutaneous pigmentation. Cushing’s syndrome, due to primary pigmented nodular adrenocortical disease (PPNAD), is described in 25% of the cases.Case reportWoman, 21-year-old, was refered for secondary amenorrhea. Med...

Introduction: The tendency to eat salty foods is an individualized matter. Aldosterone plays an important role in this increase in salt appetite. In this study the effects of different salt concentrations during pregnancy on Na and aldosterone level, adrenal gland and salt appetite of rat’s infants and the relation of salt consumption with Bp were studied.Method: Eight groups of rats, six rats in each group, (ones of male and five female) having 200...

Introduction: There are emerging reports showing the relationship between human immunodeficiency virus (HIV), Covid-19 and adrenal insufficiency. This was attributed to thrombotic events and necrosis, leading to hypoadrenalism. The HIV virus can also lead to Addison”s disease due to destruction of adrenal gland. Prevalence of adrenal infarction with COVID-19 was found to be 23% and 88% this was shown to be affecting both adrenal glands. Case report:...

Introduction: Basal ganglia calcification or Fahr’s Syndrome is a rare form of neurological disorder. Its prevalence goes from 2 to 12.5 %. It can be primary (idiopathic) or secondary (from metabolic disorders especially from hypoparathyroidism).We present the case of a female patient with hypoparathyroidism and secondary Fahr’s Disease.Case description: The patient L.J. 61 years old, from Pogradec, Albania, who came to the emergency room wit...

Introduction: There have been described that about 50% of women diagnosed with PCO-S, present lipid metabolism disorders, insulin resistance and incorrect blood pressure. They suffer not only from fertility disorders, but also present a risk of metabolic complications such as: obesity, type 2 diabetes and hypertension, which increase diet-related cancers and cardiovascular risk.Aim: To explore if serum omentin concentration could be an indicator of cardi...

Spontaneous remission of Cushing disease might be a phase of cyclic disease, but could also be explained by an ACTH-microadenoma infarction or hemorrhage. True remission must be differentiated from cyclic Cushing’s disease with prolonged follow up. 63-years-old female patient was referred to endocrinologist’s and presented with uncontrolled hypertension, type 2 diabetes, central obesity, hirsutism, swelling of the face and legs and a ’buffalo hump’. After a...